Headache Caused by Brain Metastases of Castration-resistant Prostate Cancer during Cabazitaxel Therapy

Complete Radiologic Response in Metastatic Castration-Resistant Prostate Cancer Treated with Cabazitaxel

Prolonged therapy with cabazitaxel in an octogenarian with metastatic castration-resistant prostate cancer.

Case Report A 73-year-old man with a past medical history of diabetes and gout was noted by his urologist to have an abnormal digital rectal examination in April 1997. Core biopsies of the prostate were performed, revealing Gleason 7 (4 3) disease comprising roughly 50% of 6 pecimens. The patient was treated with brachytherapy, and the paient’s prostatic-specific antigen (PSA) level declined to...

Single Orbital Metastasis in Castration-Resistant Prostate Cancer

Introduction: Orbital metastasis of prostate cancer (PC) is very rare and even more unique in castration-resistant PC (CRPC). In this scenario, choline positron emission tomography/computed tomography (choline PET/CT) is the gold-standard restaging method of choice available in our setting, and new anti-androgens treatments show improvement in overall survival. Case presentation: We report the...

Mechanisms Behind Growth Of Castration-Resistant Prostate Cancer Bone Metastases

Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). The majority of CRPC tumors show androgen receptor (AR) activity despite castrate levels of circulating testos...

Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer

Reactive oxygen species (ROS) production induced by taxanes in cancer cells may influence the taxane-induced cell death or the drug resistance. We investigated the correlation between the cytotoxic effect of taxanes and ROS production in human castration-resistant prostate cancer (CRPC) cell lines. Three human prostate cancer cell lines were treated with increasing concentrations of docetaxel o...